Programmed cell death (apoptosis) occurs in almost all cells, including oocytes and embryos. How to detect some physiological changes during the entire development or apoptosis process without damaging the embryo and cells?
Scientist David Keefe of the MBL laboratory in the United States and others used non-damaging micro-testing technology (The self-referencing system) to detect the morphology of fertilized eggs under H2O2 treatment and changes in extracellular K +. It was detected that apoptosis was activated by substances such as H2O2, and a significant K + outflow occurred, during which the cells contracted. When the cell starts programmed death, it will activate the potassium ion channel. Using "non-damaging micro-measurement technology", it can detect the change of potassium ion concentration outside the oocyte and the embryo, and metabolize oxygen consumption; difference.
By studying the changing mechanism of cell morphology and ion current, it can provide feasible ideas for solving premature birth, cell apoptosis and aging.
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