Researchers from the Department of Pathology of Southern Medical University, Southern Hospital, through the analysis of three phenothiazine drugs, discussed the potential antitumor mechanism of three phenothiazine drugs. The researchers pointed out that phenothiazine drugs may have potential anti-tumor effects, and their tumor-associated target proteins play a key role in the process of cell signal cascade transduction.
There are many kinds of anti-tumor chemotherapy drugs. According to the traditional classification method, the chemotherapy drugs can be divided into alkylating agents, antimetabolites, anticancer antibiotics, plants, hormones, and miscellaneous drugs. The influence of kinetics can be divided into cell cycle specific drugs and cell cycle non-specific drugs. However, chemotherapy drugs have more adverse reactions, such as nausea, vomiting, hair loss, and pain. Chemotherapy is also suffering from great pain.
Phenothiazines are widely used and relatively mature antipsychotic drugs. They mainly act on central dopamine receptors, and have sedative, antiemetic, antipsychotic, and body temperature lowering effects. The representative drug is chlorpromazine . Previous studies have found that chlorpromazine can enhance the cytotoxic effect of tamoxifen on breast cancer, phenothiazines can enhance the sensitivity of cisplatin and other chemotherapy drugs and reverse the resistance of tumor cells to chemotherapy drugs. These results show the characteristics of adjuvant chemotherapy.
In this article, the researchers analyzed the three phenothiazine drugs to explore the potential antitumor mechanism of the three phenothiazine drugs.
First, the researchers predict the target proteins that can interact with chlorpromazine, fluphenazine, and trifluoperazine, and then take the intersection of the target proteins of the three drugs, and enrich the cell signaling pathway of the intersection protein and related disease. Collect and extract the tumor-enriched class, and then clarify the mechanism of action of these target proteins in the tumor through protein interaction network regulation analysis, thereby clarifying the potential anti-tumor mechanism of action of phenothiazine drugs.
Cell signaling pathway enrichment and related disease enrichment results show that the highest-scoring category is tumors. Among the target proteins that belong to the tumor category, they include Wnt, MAPK, retinoic acid receptor and other signaling pathway members. And they are related to the target protein In the process of cell signal cascade transmission, MAPK8 can indirectly act on target proteins CDK2, IGF1R, GSK3B, RARA, FGFR2 and MAPK10 and thus affect the division and proliferation of tumor cells. Therefore, phenothiazines may have potential antitumor effects , Its tumor-related target protein plays a key role in the process of cell signaling cascade transduction.
This study investigated the potential anti-tumor mechanisms of three phenothiazine drugs in order to be able to use them reasonably in the chemotherapy of tumors, reduce the side effects of chemotherapy in tumor patients, improve the tolerance of patients to chemotherapy, and then enhance The tumor suppression efficiency improves the survival rate of patients.
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