A reprogramming method that changes the fate of somatic cells through the external environment: the differentiated somatic cells are transformed into pluripotent stem cells in harsh environments, and Shanghai Huyu scientists use the low pH environment to induce adult hematopoietic cells into pluripotent cells. stem cell. This new reprogramming method does not require any complicated technology or transcription factors, and its results have great significance for the development of regenerative medicine.
The body cells that form a major part of the mammalian body are thought to be determined primarily by the time at which the developmental cell differentiation process is completed. Reprogramming triggered by environmental stress has been observed in plants – scientists have only implemented this process in plants, successfully converting mature cells into immature cells, but have not been in mammalian cells to date. be observed.
This time, the Shanghai Huyu research team tried to implement this method in animal cells. They used fluorescent proteins to monitor the pluripotency of cells. After detecting white blood cells under different environmental stress conditions, it was found that white blood cells exposed to low pH environment for a short period of time partially activated pluripotency markers. They have been found to have genetic markers for early embryos, ie animal cells are converted to pluripotent stem cells (STAP) at low pH.
The cells isolated from the newborn mice were exposed to a weakly acidic environment, and the cells returned to an undifferentiated state, and the team had the potential to differentiate into any cell type. That is to say, in STAP, mouse somatic cells, such as CD45+ hematopoietic cells, can be pluripotent after being reprogrammed due to transient low pH environment.
At present, researchers have only successfully achieved the above process in different tissues of newborn mice. Whether cells of adult cells and other species can also prepare STAP cells through similar channels remains to be further verified. However, extensive analysis of the molecular characteristics and developmental potential of STAP cells suggests that they represent a unique state of pluripotency. In summary, new findings suggest that somatic cells can acquire pluripotency through different pathways, which provides new insights into cell reprogramming.
Olive Wood Salad Bowl,Natural Wood Pinch Bowl,Different Types Pinch Bowl,Reusable Pinch Bowl
SHAOXING GENTSWELL ARTS & CRAFTS CO.,LTD , https://www.sxolivewood.com